Editors' Picks

Retand LTR-retrotransposons in plants: a long way from pol to 3'LTR. 

Vicient CM.

Mob DNA. 2025 Apr 2;16(1):15. doi: 10.1186/s13100-025-00354-z.

PMID: 40176144

Reactivation of retrotransposable elements is associated with environmental stress and ageing. 

Della Valle F, Reddy P, Aguirre Vazquez A, Izpisua Belmonte JC.

Nat Rev Genet. 2025 Apr 2. doi: 10.1038/s41576-025-00829-y. Online ahead of print.

PMID: 40175591 Review.

A LTR retrotransposon insertion leads to leafy phenotype in maize by elevating ZmOM66 expression. 

Du X, Xu Z, Lu J, Chen Y, Gao X, Zhang J, He C, Huang L, Guo W, Cui Y, Wang X, Ai J, Li L, Cui Y, Liu Y, Fu J, Gu R, Wang J, Wang G.

Nat Commun. 2025 Apr 2;16(1):3152. doi: 10.1038/s41467-025-57811-9.

PMID: 40175370

Unveiling Cas8 dynamics and regulation within a transposon-encoded Cascade-TniQ complex. 

Patel AC, Sinha S, Arantes PR, Palermo G.

Proc Natl Acad Sci U S A. 2025 Apr 8;122(14):e2422895122. doi: 10.1073/pnas.2422895122. Epub 2025 Apr 2.

PMID: 40172964

Reprogramming site-specific retrotransposon activity to new DNA sites. 

Fell CW, Villiger L, Lim J, Hiraizumi M, Tagliaferri D, Yarnall MTN, Lee A, Jiang K, Kayabolen A, Krajeski RN, Schmitt-Ulms C, Ramani H, Yousef SM, Roberts N, Vakulskas CA, Nishimasu H, Abudayyeh OO, Gootenberg JS.

Nature. 2025 Apr 9. doi: 10.1038/s41586-025-08877-4. Online ahead of print.

PMID: 40205048

Transposable element dynamics in Xenopus laevis embryogenesis: a tale of two coexisting subgenomes. 

Tittarelli E, Carotti E, Carducci F, Barucca M, Canapa A, Biscotti MA.

Mob DNA. 2025 Apr 9;16(1):17. doi: 10.1186/s13100-025-00350-3.

PMID: 40200366 

Traffic Jam activates the Flamenco piRNA cluster locus and the Piwi pathway to ensure transposon silencing and Drosophila fertility. 

Rivera AJ, Lee JR, Gupta S, Yang L, Goel RK, Zaia J, Lau NC.

Cell Rep. 2025 Apr 6:115354. doi: 10.1016/j.celrep.2025.115354. Online ahead of print.

PMID: 40209716

Transposon expression and repression in skeletal muscle. 

Borok MJ, Zaidan L, Relaix F.

Mob DNA. 2025 Apr 11;16(1):18. doi: 10.1186/s13100-025-00352-1.

PMID: 40217332 Review.

Mechanism of mammalian transcriptional repression by noncoding RNA. 

Tlučková K, Kaczmarek B, Salmazo A, Bernecky C.

Nat Struct Mol Biol. 2025 Apr;32(4):607-612. doi: 10.1038/s41594-024-01448-7. Epub 2025 Jan 6.

PMID: 39762629

In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-ET

Sven Klumpe, Kirsten A. Senti, Florian Beck, Jenny Sachweh, Bernhard Hampoelz, Paolo Ronchi, Viola Oorschot, Marlene Brandstetter, Assa Yeroslaviz, John A.G. Briggs, Julius Brennecke, Martin Beck, Jürgen M. Plitzko

Cell, Volume 188, Issue 8, 2094 - 2110.e18
 

Zygotic activation of transposable elements during zebrafish early embryogenesis. 

 Li B, Li T, Wang D, Yang Y, Tan P, Wang Y, Yang YG, Jia S, Au KF.

Nat Commun. 2025 Apr 18;16(1):3692. doi: 10.1038/s41467-025-58863-7.

PMID: 40246845

Cross-species analysis of the nuclease Artemis highlights its evolving function in domesticating RAG-like transposons and residues that are crucial for activity. 

Huang Z, Cai Z, Tao X, Wang X, Tian X, Chen F, Li Z, Xu A, Yuan S.

PLoS Biol. 2025 Apr 17;23(4):e3003056. doi: 10.1371/journal.pbio.3003056. eCollection 2025 Apr.

PMID: 40245028

TRUSTing transposable elements to create ultra-clean transgene insertions. 

Swanson R, Diehl B, Slotkin RK.

New Phytol. 2025 Apr 18. doi: 10.1111/nph.70157. Online ahead of print.

PMID: 40251856 

Comprehensive Genomic Analysis Reveals Novel Transposable Element-Derived MicroRNA Regulating Caste Differentiation in Honeybees. 

Jiang Y, Hu J, Li Y, Tang X, Peng X, Xie L, Song H, Zhou Z, Xu J.

Mol Biol Evol. 2025 Apr 1;42(4):msaf074. doi: 10.1093/molbev/msaf074.

PMID: 40154540

Structural features of somatic and germline retrotransposition events in humans. 

Nummi P, Cajuso T, Norri T, Taira A, Kuisma H, Välimäki N, Lepistö A, Renkonen-Sinisalo L, Koskensalo S, Seppälä TT, Ristimäki A, Tahkola K, Mattila A, Böhm J, Mecklin JP, Siili E, Pasanen A, Heikinheimo O, Bützow R, Karhu A, Burns KH, Palin K, Aaltonen LA.

Mob DNA. 2025 Apr 22;16(1):20. doi: 10.1186/s13100-025-00357-w.

PMID: 40264183

Gag proteins encoded by endogenous retroviruses are required for zebrafish development. 

Chang NC, Wells JN, Wang AY, Schofield P, Huang YC, Truong VH, Simoes-Costa M, Feschotte C.

Proc Natl Acad Sci U S A. 2025 May 6;122(18):e2411446122. doi: 10.1073/pnas.2411446122. Epub 2025 Apr 28.

PMID: 40294259

Transposable elements as instructors of the immune system. 

Schmidleithner L, Stüve P, Feuerer M.

Nat Rev Immunol. 2025 Apr 29. doi: 10.1038/s41577-025-01172-3. Online ahead of print.

PMID: 40301669 Review.

Mobile genetic elements in Klebsiella pneumoniae. 

Pan T, Li Q.

J Bacteriol. 2025 Apr 29:e0001225. doi: 10.1128/jb.00012-25. Online ahead of print.

PMID: 40298401 Review.

METTL3-dependent m6A RNA methylation regulates transposable elements and represses human naïve pluripotency through transposable element-derived enhancers. 

Zhang W, Fu H, Huang Y, Zeng M, Ouyang X, Wang X, Ruan D, Ma L, Hu X, Guo J, Galardi JW, Dougan G, Yeung WSB, Li L, Liu J, Feschotte C, Liu P.

Nucleic Acids Res. 2025 Apr 22;53(8):gkaf349. doi: 10.1093/nar/gkaf349.

PMID: 40298111

LINE-1 ribonucleoprotein condensates bind DNA to enable nuclear entry during mitosis. 

Zernia S, Ettefa F, Sil S, Koeman C, Deplazes-Lauber J, Freitag M, Holt LJ, Stigler J.

Sci Adv. 2025 May 2;11(18):eadt9318. doi: 10.1126/sciadv.adt9318. Epub 2025 May 2.

PMID: 40315332

LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells

Lamisa Ataei, Juan Zhang, Simon Monis, Krystyna Giemza, Kirti Mittal, Joshua Yang, Mayu Shimomura, Brian McStay, Michael D. Wilson and Miguel Ramalho-Santos

Genes Dev. 2025; 39: 280-298

https://pubmed.ncbi.nlm.nih.gov/39797762/

Targeted detection of endogenous LINE-1 proteins and ORF2p interactions. 

Nielsen MI, Wolters JC, Bringas OGR, Jiang H, Di Stefano LH, Oghbaie M, Hozeifi S, Nitert MJ, van Pijkeren A, Smit M, Ter Morsche L, Mourtzinos A, Deshpande V, Taylor MS, Chait BT, LaCava J.

Mob DNA. 2025 Feb 6;16(1):3. doi: 10.1186/s13100-024-00339-4.

PMID: 39915890

"Arc - A viral vector of memory and synaptic plasticity". 

Sullivan KR, Ravens A, Walker AC, Shepherd JD.

Curr Opin Neurobiol. 2025 Feb 15;91:102979. doi: 10.1016/j.conb.2025.102979. Online ahead of print.

PMID: 39956025 Review.

A genome-wide study of ruminants uncovers two endogenous retrovirus families recently active in goats. 

Verneret M, Leroux C, Faraut T, Navratil V, Lerat E, Turpin J.

Mob DNA. 2025 Feb 17;16(1):4. doi: 10.1186/s13100-024-00337-6.

PMID: 39962507

A family of Tn7-like transposons evolved to target CRISPR repeats. 

Chacon Machado L, Peters JE.

Mob DNA. 2025 Feb 18;16(1):5. doi: 10.1186/s13100-025-00344-1.

PMID: 39966887

Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. 

M'Angale PG, Lemieux A, Liu Y, Wang S, Zinter M, Alegre G, Simkin A, Budnik V, Kelch BA, Thomson T.

PLoS Biol. 2025 Feb 18;23(2):e3002983. doi: 10.1371/journal.pbio.3002983. eCollection 2025 Feb.

PMID: 39964983

A genome-wide study of ruminants uncovers two endogenous retrovirus families recently active in goats. 

Verneret M, Leroux C, Faraut T, Navratil V, Lerat E, Turpin J.

Mob DNA. 2025 Feb 17;16(1):4. doi: 10.1186/s13100-024-00337-6.

PMID: 39962507

Neural development goes retro: Gags as essential modulators of synapse formation. 

Chang YH, Dubnau J.

PLoS Biol. 2025 Feb 19;23(2):e3003032. doi: 10.1371/journal.pbio.3003032. eCollection 2025 Feb.

PMID: 39970178

The histone demethylase dLsd1 regulates organ size by silencing transposable elements. 

Selmi I, Texier M, Aguirrenbegoa M, Merce C, Fraisse-Lepourry L, Mugat B, Mohamed M, Chambeyron S, Cribbs D, Di Stefano L.

Commun Biol. 2025 Feb 20;8(1):272. doi: 10.1038/s42003-025-07724-6.

PMID: 39979483

Transposon-host arms race: a saga of genome evolution. 

Iwasaki YW, Shoji K, Nakagwa S, Miyoshi T, Tomari Y.

Trends Genet. 2025 Feb 19:S0168-9525(25)00009-5. doi: 10.1016/j.tig.2025.01.009. Online ahead of print.

PMID: 39979178 Review.

Transposable elements may enhance antiviral resistance in HIV-1 elite controllers. 

Singh M, Leddy SM, Iñiguez LP, Bendall ML, Nixon DF, Feschotte C.

Genome Biol. 2025 Feb 24;26(1):28. doi: 10.1186/s13059-025-03484-y.

PMID: 39988678

The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation. 

Hermant C, Mourra-Díaz CM, Oomen ME, Altamirano-Pacheco L, Pal M, Nakatani T, Torres-Padilla ME.

Genes Dev. 2025 Feb 27. doi: 10.1101/gad.352270.124. Online ahead of print.

PMID: 40015990

Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency. 

Solovyov A, Behr JM, Hoyos D, Banks E, Drong AW, Thornlow B, Zhong JZ, Garcia-Rivera E, McKerrow W, Chu C, Arisdakessian C, Zaller DM, Kamihara J, Diao L, Fromer M, Greenbaum BD.

Nat Commun. 2025 Feb 28;16(1):2049. doi: 10.1038/s41467-025-57271-1.

PMID: 40021663

Multi-ancestry GWAS reveals loci linked to human variation in LINE-1- and Alu-insertion numbers. 

Bravo JI, Zhang L, Benayoun BA.

Transl Med Aging. 2025;9:25-40. doi: 10.1016/j.tma.2025.02.001. Epub 2025 Feb 13.

PMID: 40051556

n-cell structure and snapshots of copia retrotransposons in intact tissue by cryoelectron tomography. 

Klumpe S, Senti KA, Beck F, Sachweh J, Hampoelz B, Ronchi P, Oorschot V, Brandstetter M, Yeroslaviz A, Briggs JAG, Brennecke J, Beck M, Plitzko JM.

Cell. 2025 Mar 3:S0092-8674(25)00159-X. doi: 10.1016/j.cell.2025.02.003. Online ahead of print.

PMID: 40049165

Structural mechanism of LINE-1 target-primed reverse transcription. 

Ghanim GE, Hu H, Boulanger J, Nguyen THD.

Science. 2025 Mar 6:eads8412. doi: 10.1126/science.ads8412. Online ahead of print.

PMID: 40048554

Telomeric transposons are pervasive in linear bacterial genomes. 

Hsieh SC, Fülöp M, Schargel R, Petassi MT, Barabas O, Peters JE.

Science. 2025 Mar 6:eadp1973. doi: 10.1126/science.adp1973. Online ahead of print.

PMID: 40048552

Marine vs. terrestrial: links between the environment and the diversity of Copia retrotransposon in metazoans. 

Klai K, Farhat S, Lamothe L, Higuet D, Bonnivard É.

Mob DNA. 2025 Mar 8;16(1):9. doi: 10.1186/s13100-025-00346-z.

PMID: 40055832

Tandem LTR-retrotransposon structures are common and highly polymorphic in plant genomes. 

Morales-Díaz N, Sushko S, Campos-Dominguez L, Kopalli V, Golicz AA, Castanera R, Casacuberta JM.

Mob DNA. 2025 Mar 12;16(1):10. doi: 10.1186/s13100-025-00347-y.

PMID: 40075446

Association of a 7.9 kb Endogenous Retrovirus Insertion in Intron 1 of CD36 with Obesity and Fat Measurements in Sheep. 

Saleh AA, Moawad AS, Yang N, Zheng Y, Chen C, Wang X, Gao B, Song C.

Mob DNA. 2025 Mar 14;16(1):12. doi: 10.1186/s13100-025-00349-w.

PMID: 40087777

A telomere-to-telomere genome assembly of cotton provides insights into centromere evolution and short-season adaptation. 

Hu G, Wang Z, Tian Z, Wang K, Ji G, Wang X, Zhang X, Yang Z, Liu X, Niu R, Zhu D, Zhang Y, Duan L, Ma X, Xiong X, Kong J, Zhao X, Zhang Y, Zhao J, He S, Grover CE, Su J, Feng K, Yu G, Han J, Zang X, Wu Z, Pan W, Wendel JF, Ma X.

Nat Genet. 2025 Mar 17. doi: 10.1038/s41588-025-02130-4. Online ahead of print.

PMID: 40097785

Polymorphic transposable elements contribute to variation in recombination landscapes. 

Huang Y, Gao ZY, Ly K, Lin L, Lambooij JP, King EG, Janssen A, Wei KH, Lee YCG.

Proc Natl Acad Sci U S A. 2025 Mar 25;122(12):e2427312122. doi: 10.1073/pnas.2427312122. Epub 2025 Mar 18.

PMID: 40100633

Widespread impact of transposable elements on the evolution of post-transcriptional regulation in the cotton genus Gossypium. 

Tian X, Wang R, Liu Z, Lu S, Chen X, Zhang Z, Liu F, Li H, Zhang X, Wang M.

Genome Biol. 2025 Mar 17;26(1):60. doi: 10.1186/s13059-025-03534-5.

PMID: 40098207

The domesticated transposon protein L1TD1 associates with its ancestor L1 ORF1p to promote LINE-1 retrotransposition. 

Kavaklioglu G, Podhornik A, Vcelkova T, Marjanovic J, Beck MA, Phan-Canh T, Mair T, Miccolo C, Drino A, Doni M, Egger G, Chiocca S, Modic M, Seiser C.

Elife. 2025 Mar 20;13:RP96850. doi: 10.7554/eLife.96850.

PMID: 40112032

IS26 carrying bla_KPC-2 mediates carbapenem resistance heterogeneity in extensively drug-resistant Klebsiella pneumoniae isolated from clinical sites. 

Guo Z, Qin X, Yue M, Wu L, Li N, Su J, Jiang M.

Mob DNA. 2025 Mar 24;16(1):13. doi: 10.1186/s13100-025-00351-2.

PMID: 40128793

LocusMasterTE: integrating long-read RNA sequencing improves locus-specific quantification of transposable element expression. 

Lee S, Barbour JA, Tam YM, Yang H, Huang Y, Wong JWH.

Genome Biol. 2025 Mar 26;26(1):72. doi: 10.1186/s13059-025-03522-9.

PMID: 40140852

Subtelomeric repeat expansion in Hydractinia symbiolongicarpus chromosomes. 

Kon T, Kon-Nanjo K, Simakov O.

Mob DNA. 2025 Mar 25;16(1):14. doi: 10.1186/s13100-025-00355-y.

PMID: 40134021

Chromatin accessibility landscape of mouse early embryos revealed by single-cell NanoATAC-seq2. 

Li M, Jiang Z, Xu X, Wu X, Liu Y, Chen K, Liao Y, Li W, Wang X, Guo Y, Zhang B, Wen L, Kee K, Tang F.

Science. 2025 Mar 28;387(6741):eadp4319. doi: 10.1126/science.adp4319. Epub 2025 Mar 28.

PMID: 40146829

ALS molecular subtypes are a combination of cellular and pathological features learned by deep multiomics classifiers. 

O'Neill K, Shaw R, Bolger I; NYGC ALS Consortium; Tam OH, Phatnani H, Gale Hammell M.

Cell Rep. 2025 Mar 25;44(3):115402. doi: 10.1016/j.celrep.2025.115402. Epub 2025 Mar 10.

PMID: 40067829

LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells

Lamisa Ataei, Juan Zhang, Simon Monis, Krystyna Giemza, Kirti Mittal, Joshua Yang, Mayu Shimomura, Brian McStay, Michael D. Wilson and Miguel  Ramalho-Santos

Genes Dev. 2025; 39: 280-298

PMID: 39797762

Targeted detection of endogenous LINE-1 proteins and ORF2p interactions. 

Nielsen MI, Wolters JC, Bringas OGR, Jiang H, Di Stefano LH, Oghbaie M, Hozeifi S, Nitert MJ, van Pijkeren A, Smit M, Ter Morsche L, Mourtzinos A, Deshpande V, Taylor MS, Chait BT, LaCava J.

Mob DNA. 2025 Feb 6;16(1):3. doi: 10.1186/s13100-024-00339-4.

PMID: 39915890

"Arc - A viral vector of memory and synaptic plasticity". 

Sullivan KR, Ravens A, Walker AC, Shepherd JD.

Curr Opin Neurobiol. 2025 Feb 15;91:102979. doi: 10.1016/j.conb.2025.102979. Online ahead of print.

PMID: 39956025 Review.

A genome-wide study of ruminants uncovers two endogenous retrovirus families recently active in goats. 

Verneret M, Leroux C, Faraut T, Navratil V, Lerat E, Turpin J.

Mob DNA. 2025 Feb 17;16(1):4. doi: 10.1186/s13100-024-00337-6.

PMID: 39962507

A family of Tn7-like transposons evolved to target CRISPR repeats. 

Chacon Machado L, Peters JE.

Mob DNA. 2025 Feb 18;16(1):5. doi: 10.1186/s13100-025-00344-1.

PMID: 39966887

Capsid transfer of the retrotransposon Copia controls structural synaptic plasticity in Drosophila. 

M'Angale PG, Lemieux A, Liu Y, Wang S, Zinter M, Alegre G, Simkin A, Budnik V, Kelch BA, Thomson T.

PLoS Biol. 2025 Feb 18;23(2):e3002983. doi: 10.1371/journal.pbio.3002983. eCollection 2025 Feb.

PMID: 39964983

A genome-wide study of ruminants uncovers two endogenous retrovirus families recently active in goats. 

Verneret M, Leroux C, Faraut T, Navratil V, Lerat E, Turpin J.

Mob DNA. 2025 Feb 17;16(1):4. doi: 10.1186/s13100-024-00337-6.

PMID: 39962507

Neural development goes retro: Gags as essential modulators of synapse formation. 

Chang YH, Dubnau J.

PLoS Biol. 2025 Feb 19;23(2):e3003032. doi: 10.1371/journal.pbio.3003032. eCollection 2025 Feb.

PMID: 39970178

The histone demethylase dLsd1 regulates organ size by silencing transposable elements. 

Selmi I, Texier M, Aguirrenbegoa M, Merce C, Fraisse-Lepourry L, Mugat B, Mohamed M, Chambeyron S, Cribbs D, Di Stefano L.

Commun Biol. 2025 Feb 20;8(1):272. doi: 10.1038/s42003-025-07724-6.

PMID: 39979483

Transposon-host arms race: a saga of genome evolution. 

Iwasaki YW, Shoji K, Nakagwa S, Miyoshi T, Tomari Y.

Trends Genet. 2025 Feb 19:S0168-9525(25)00009-5. doi: 10.1016/j.tig.2025.01.009. Online ahead of print.

PMID: 39979178 Review.

Transposable elements may enhance antiviral resistance in HIV-1 elite controllers. 

Singh M, Leddy SM, Iñiguez LP, Bendall ML, Nixon DF, Feschotte C.

Genome Biol. 2025 Feb 24;26(1):28. doi: 10.1186/s13059-025-03484-y.

PMID: 39988678

The transcription factor SRF regulates MERVL retrotransposons and gene expression during zygotic genome activation. 

Hermant C, Mourra-Díaz CM, Oomen ME, Altamirano-Pacheco L, Pal M, Nakatani T, Torres-Padilla ME.

Genes Dev. 2025 Feb 27. doi: 10.1101/gad.352270.124. Online ahead of print.

PMID: 40015990

Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency. 

Solovyov A, Behr JM, Hoyos D, Banks E, Drong AW, Thornlow B, Zhong JZ, Garcia-Rivera E, McKerrow W, Chu C, Arisdakessian C, Zaller DM, Kamihara J, Diao L, Fromer M, Greenbaum BD.

Nat Commun. 2025 Feb 28;16(1):2049. doi: 10.1038/s41467-025-57271-1.

PMID: 40021663

Centrophilic retrotransposon integration via CENH3 chromatin in Arabidopsis. 

Tsukahara S, Bousios A, Perez-Roman E, Yamaguchi S, Leduque B, Nakano A, Naish M, Osakabe A, Toyoda A, Ito H, Edera A, Tominaga S, Juliarni, Kato K, Oda S, Inagaki S, Lorković Z, Nagaki K, Berger F, Kawabe A, Quadrana L, Henderson I, Kakutani T.

Nature. 2025 Jan 1. doi: 10.1038/s41586-024-08319-7. Online ahead of print.

PMID: 39743586

Transposon exonization generates new protein-coding sequences. 

Hong Y, Shen X.

Mol Cell. 2025 Jan 2;85(1):7-8. doi: 10.1016/j.molcel.2024.12.009.

PMID: 39753108

Transcriptional coupling of telomeric retrotransposons with the cell cycle. 

Liu M, Xie XJ, Li X, Ren X, Sun JL, Lin Z, Hemba-Waduge RU, Ji JY.

Sci Adv. 2025 Jan 3;11(1):eadr2299. doi: 10.1126/sciadv.adr2299. Epub 2025 Jan 3.

PMID: 39752503

Evolutionary origins of archaeal and eukaryotic RNA-guided RNA modification in bacterial IS110 transposons. 

Vaysset H, Meers C, Cury J, Bernheim A, Sternberg SH.

Nat Microbiol. 2025 Jan 2. doi: 10.1038/s41564-024-01889-2. Online ahead of print.

PMID: 39747689

POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer. 

Mann KM.

Trends Cell Biol. 2025 Jan;35(1):4-5. doi: 10.1016/j.tcb.2024.11.002. Epub 2024 Nov 14.

PMID: 39547880

Insulin signaling regulates R2 retrotransposon expression to orchestrate transgenerational rDNA copy number maintenance. 

Nelson JO, Slicko A, Raz AA, Yamashita YM.

Nat Commun. 2025 Jan 4;16(1):399. doi: 10.1038/s41467-024-55725-6.

PMID: 39755735

SINE retrotransposons import polyadenylation signals to 3'UTRs in dog (Canis familiaris). 

Choi JD, Del Pinto LA, Sutter NB.

Mob DNA. 2025 Jan 4;16(1):1. doi: 10.1186/s13100-024-00338-5.

PMID: 39755632

RNA control of reverse transcription in a diversity-generating retroelement. 

Handa S, Biswas T, Chakraborty J, Ghosh G, Paul BG, Ghosh P.

Nature. 2025 Jan 8. doi: 10.1038/s41586-024-08405-w. Online ahead of print.

PMID: 39779855

Activity of the mammalian DNA transposon piggyBat from Myotis lucifugus is restricted by its own transposon ends. 

Hickman AB, Lannes L, Furman CM, Hong C, Franklin L, Ghirlando R, Ghosh A, Luo W, Konstantinidou P, Lorenzi HA, Grove A, Haase AD, Wilson MH, Dyda F.

Nat Commun. 2025 Jan 7;16(1):458. doi: 10.1038/s41467-024-55784-9.

PMID: 39774116

Systematically developing a registry of splice-site creating variants utilizing massive publicly available transcriptome sequence data. 

Iida N, Okada A, Kobayashi Y, Chiba K, Yatabe Y, Shiraishi Y.

Nat Commun. 2025 Jan 9;16(1):426. doi: 10.1038/s41467-024-55185-y.

PMID: 39788962

Horizontal transfer and recombination fuel Ty4 retrotransposon evolution in Saccharomyces. 

Chen J, Garfinkel DJ, Bergman CM.

Genome Biol Evol. 2025 Jan 9:evaf004. doi: 10.1093/gbe/evaf004. Online ahead of print.

PMID: 39786570

LINE1 elements at distal junctions of rDNA repeats regulate nucleolar organization in human embryonic stem cells. 

Ataei L, Zhang J, Monis S, Giemza K, Mittal K, Yang J, Shimomura M, McStay B, Wilson MD, Ramalho-Santos M.

Genes Dev. 2024 Dec 20. doi: 10.1101/gad.351979.124. Online ahead of print.

PMID: 39797762

LINE-1, the NORth star of nucleolar organization. 

Matsuo M, Cristofari G.

Genes Dev. 2025 Jan 10. doi: 10.1101/gad.352583.124. Online ahead of print.

PMID: 39794124 Review.

Exploring the diversity of anti-defense systems across prokaryotes, phages and mobile genetic elements. 

Tesson F, Huiting E, Wei L, Ren J, Johnson M, Planel R, Cury J, Feng Y, Bondy-Denomy J, Bernheim A.

Nucleic Acids Res. 2025 Jan 7;53(1):gkae1171. doi: 10.1093/nar/gkae1171.

PMID: 39657785

Multi-tissue characterization of the constitutive heterochromatin proteome in Drosophila identifies a link between satellite DNA organization and transposon repression. 

Chavan A, Skrutl L, Uliana F, Pfister M, Brändle F, Tirian L, Baptista D, Handler D, Burke D, Sintsova A, Beltrao P, Brennecke J, Jagannathan M.

PLoS Biol. 2025 Jan 15;23(1):e3002984. doi: 10.1371/journal.pbio.3002984. eCollection 2025 Jan.

PMID: 39813297

Maintenance of long-term transposable element activity through regulation by nonautonomous elements. 

Omole AD, Czuppon P.

Genetics. 2025 Jan 15:iyae209. doi: 10.1093/genetics/iyae209. Online ahead of print.

PMID: 39810601

Harnessing eukaryotic retroelement proteins for transgene insertion into human safe-harbor loci. 

Zhang X, Van Treeck B, Horton CA, McIntyre JJR, Palm SM, Shumate JL, Collins K.

Nat Biotechnol. 2025 Jan;43(1):42-51. doi: 10.1038/s41587-024-02137-y. Epub 2024 Feb 20.

PMID: 38379101

A retrotransposon for site-specific gene transfer
Fred Dyda & Alison B. Hickman 
News & Views | 18 March 2024 Nature Biotechnology 43 | PMID: 38499759

An atlas of transcription initiation reveals regulatory principles of gene and transposable element expression in early mammalian development. 

Oomen ME, Rodriguez-Terrones D, Kurome M, Zakhartchenko V, Mottes L, Simmet K, Noll C, Nakatani T, Mourra-Diaz CM, Aksoy I, Savatier P, Göke J, Wolf E, Kaessmann H, Torres-Padilla ME.

Cell. 2025 Jan 16:S0092-8674(24)01426-0. doi: 10.1016/j.cell.2024.12.013. Online ahead of print.

PMID: 39837330

Dynamic co-evolution of transposable elements and the piRNA pathway in African cichlid fishes. 

Almeida MV, Blumer M, Yuan CU, Sierra P, Price JL, Quah FX, Friman A, Dallaire A, Vernaz G, Putman ALK, Smith AM, Joyce DA, Butter F, Haase AD, Durbin R, Santos ME, Miska EA.

Genome Biol. 2025 Jan 22;26(1):14. doi: 10.1186/s13059-025-03475-z.

PMID: 39844208

The rate and spectrum of new mutations in mice inferred by long-read sequencing. 

López-Cortegano E, Chebib J, Jonas A, Vock A, Künzel S, Keightley PD, Tautz D.

Genome Res. 2025 Jan 22;35(1):43-54. doi: 10.1101/gr.279982.124.

PMID: 39622636

Transposable element activity captures human pluripotent cell states. 

Levin-Ferreyra F, Kodali S, Cui Y, Pashos ARS, Pessina P, Brumbaugh J, Di Stefano B.

EMBO Rep. 2025 Jan;26(2):329-352. doi: 10.1038/s44319-024-00343-y. Epub 2024 Dec 12.

PMID: 39668246

Transposon proliferation drives genome architecture and regulatory evolution in wild and domesticated peppers. 

Zhang K, Yu H, Zhang L, Cao Y, Li X, Mei Y, Wang X, Zhang Z, Li T, Jin Y, Fan W, Guan C, Wang Y, Zhou D, Chen S, Wu H, Wang L, Cheng F.

Nat Plants. 2025 Jan 28. doi: 10.1038/s41477-025-01905-1. Online ahead of print.

PMID: 39875669

FishPi: a bioinformatic prediction tool to link piRNA and transposable elements. 

Godden AM, Rix B, Immler S.

Mob DNA. 2025 Jan 28;16(1):2. doi: 10.1186/s13100-025-00342-3.

PMID: 39871368

The promise of CRISPR-associated transposons for bacterial functional genomics. 

Banta AB, Cuellar RA, Nadig N, Davis BC, Peters JM.

Curr Opin Microbiol. 2024 Dec 3;83:102563. doi: 10.1016/j.mib.2024.102563. Online ahead of print.

PMID: 39631148 Review

Biology and applications of CRISPR-Cas12 and transposon-associated homologs. 

Wu WY, Adiego-Pérez B, van der Oost J.

Nat Biotechnol. 2024 Dec 4. doi: 10.1038/s41587-024-02485-9. Online ahead of print.

PMID: 39633151 Review.

Gene acquisition by giant transposons primes eukaryotes for rapid evolution via horizontal gene transfer. 

Urquhart AS, Gluck-Thaler E, Vogan AA.

Sci Adv. 2024 Dec 6;10(49):eadp8738. doi: 10.1126/sciadv.adp8738. Epub 2024 Dec 6.

PMID: 39642232

Genomic evidence of a transposon-conferred adaptive response. 

Hayashi K, Fernie AR.

Cell Rep. 2024 Dec 5;43(12):115009. doi: 10.1016/j.celrep.2024.115009. Online ahead of print.

PMID: 39643972

A novel hyperactive variant of the Sleeping Beauty transposase facilitates non-viral genome engineering. 

Ochmann MT, Miskey C, Botezatu L, Sandoval-Villegas N, Diem T, Ivics Z.

Mol Ther Nucleic Acids. 2024 Nov 4;35(4):102381. doi: 10.1016/j.omtn.2024.102381. eCollection 2024 Dec 10.

PMID: 39654540 

DNA binding and transposition activity of the Sleeping Beauty transposase: role of structural stability of the primary DNA-binding domain. 

Ranjan VV, Leighton GO, Yan C, Arango M, Lustig J, Corona RI, Guo JT, Nesmelov YE, Ivics Z, Nesmelova IV.

Nucleic Acids Res. 2024 Dec 9:gkae1188. doi: 10.1093/nar/gkae1188. Online ahead of print.

PMID: 39657726

Regulation of human interferon signaling by transposon exonization. 

Pasquesi GIM, Allen H, Ivancevic A, Barbachano-Guerrero A, Joyner O, Guo K, Simpson DM, Gapin K, Horton I, Nguyen LL, Yang Q, Warren CJ, Florea LD, Bitler BG, Santiago ML, Sawyer SL, Chuong EB.

Cell. 2024 Dec 10:S0092-8674(24)01333-3. doi: 10.1016/j.cell.2024.11.016. Online ahead of print.

PMID: 39672162

Reactivation of senescence-associated endogenous retroviruses by ATF3 drives interferon signaling in aging. 

Mao J, Zhang Q, Zhuang Y, Zhang Y, Li L, Pan J, Xu L, Ding Y, Wang M, Cong YS.

Nat Aging. 2024 Dec;4(12):1794-1812. doi: 10.1038/s43587-024-00745-6. Epub 2024 Nov 14.

PMID: 39543280

Transposon load and RNAi loss synergize to drive intraspecies diversity in Cryptococcus. 

Iracane E, Buscaino A.

Proc Natl Acad Sci U S A. 2024 Dec 24;121(52):e2422896121. doi: 10.1073/pnas.2422896121. Epub 2024 Dec 16.

PMID: 39680781 

CRISPR in mobile genetic elements: counter-defense, inter-element competition and RNA-guided transposition. 

Koonin EV, Makarova KS.

BMC Biol. 2024 Dec 18;22(1):295. doi: 10.1186/s12915-024-02090-x.

PMID: 39696488 Review.

Transposon-derived decoy fine-tunes IFN responses. 

Bordon Y.

Nat Rev Immunol. 2024 Dec 19. doi: 10.1038/s41577-024-01126-1. Online ahead of print.

PMID: 39702457 

Protein-free catalysis of DNA hydrolysis and self-integration by a ribozyme. 

Szokoli D, Mutschler H.

Nucleic Acids Res. 2024 Dec 19:gkae1224. doi: 10.1093/nar/gkae1224. Online ahead of print.

PMID: 39698822

Antibodies against endogenous retroviruses. 

Chisca M, Larouche JD, Xing Q, Kassiotis G.

Immunol Rev. 2024 Nov;328(1):300-313. doi: 10.1111/imr.13378. Epub 2024 Aug 17.

PMID: 39152687 Review.

Transposable element exonization generates a reservoir of evolving and functional protein isoforms. 

Arribas YA, Baudon B, Rotival M, Suárez G, Bonté PE, Casas V, Roubert A, Klein P, Bonnin E, Mchich B, Legoix P, Baulande S, Sadacca B, Diharce J, Waterfall JJ, Etchebest C, Carrascal M, Goudot C, Quintana-Murci L, Burbage M, Merlotti A, Amigorena S.

Cell. 2024 Dec 26;187(26):7603-7620.e22. doi: 10.1016/j.cell.2024.11.011. Epub 2024 Dec 11.

PMID: 39667937

Controlling and controlled elements: highlights of the year in mobile DNA research. 

Arkhipova IR, Burns KH, Lesage P.

Mob DNA. 2024 Dec 31;15(1):27. doi: 10.1186/s13100-024-00340-x.

PMID: 39741304 No abstract available.

Why do mobile genetic elements transfer DNA of their hosts? 

Vos M, Buckling A, Kuijper B, Eyre-Walker A, Bontemps C, Leblond P, Dimitriu T.

Trends Genet. 2024 Nov;40(11):927-938. doi: 10.1016/j.tig.2024.07.008. Epub 2024 Sep 19.

PMID: 39304387 Review.

Lysosomal catabolic activity promotes the exit of murine totipotent 2-cell state by silencing early-embryonic retrotransposons. 

Wu H, Cao L, Wen X, Fan J, Wang Y, Hu H, Ji S, Zhang Y, Ye C, Xie W, Zhang J, Xu H, Fu X.

Dev Cell. 2024 Nov 15:S1534-5807(24)00637-3. doi: 10.1016/j.devcel.2024.10.018. Online ahead of print.

PMID: 39561778

L1-ORF1p nucleoprotein can rapidly assume distinct conformations and simultaneously bind more than one nucleic acid. 

Cashen BA, Naufer MN, Morse M, McCauley MJ, Rouzina I, Jones CE, Furano AV, Williams MC.

Nucleic Acids Res. 2024 Nov 20:gkae1141. doi: 10.1093/nar/gkae1141. Online ahead of print.

PMID: 39565204

Turnover of retroelements and satellite DNA drives centromere reorganization over short evolutionary timescales in Drosophila. 

Courret C, Hemmer LW, Wei X, Patel PD, Chabot BJ, Fuda NJ, Geng X, Chang CH, Mellone BG, Larracuente AM.

PLoS Biol. 2024 Nov 21;22(11):e3002911. doi: 10.1371/journal.pbio.3002911. Online ahead of print.

PMID: 39570997

The impact of retrotransposons on zygotic genome activation and the chromatin landscape of early embryos. 

Solberg T, Kobayashi-Ishihara M, Siomi H.

Ann N Y Acad Sci. 2024 Nov 22. doi: 10.1111/nyas.15260. Online ahead of print.

PMID: 39576233 Review.

Direct observation of subunit rotation during DNA strand exchange by serine recombinases. 

Cadden GM, Schloetel JG, McKenzie G, Boocock MR, Magennis SW, Stark WM.

Nat Commun. 2024 Nov 29;15(1):10407. doi: 10.1038/s41467-024-54531-4.

PMID: 39613732

RNA m⁵C oxidation by TET2 regulates chromatin state and leukaemogenesis. 

Zou Z, Dou X, Li Y, Zhang Z, Wang J, Gao B, Xiao Y, Wang Y, Zhao L, Sun C, Liu Q, Yu X, Wang H, Hong J, Dai Q, Yang FC, Xu M, He C.

Nature. 2024 Oct 2. doi: 10.1038/s41586-024-07969-x. Online ahead of print.

PMID: 39358506

Transposable elements in Drosophila montana from harsh cold environments. 

Tahami MS, Vargas-Chavez C, Poikela N, Coronado-Zamora M, González J, Kankare M.

Mob DNA. 2024 Oct 1;15(1):18. doi: 10.1186/s13100-024-00328-7.

PMID: 3935463

Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily. 

Schargel RD, Qayyum MZ, Tanwar AS, Kalathur RC, Kellogg EH.

Nat Struct Mol Biol. 2024 Oct 1. doi: 10.1038/s41594-024-01394-4. Online ahead of print.

PMID: 39354233

Alu insertion-mediated dsRNA structure formation with pre-existing Alu elements as a disease-causing mechanism. 

Masson E, Maestri S, Bordeau V, Cooper DN, Férec C, Chen JM.

Am J Hum Genet. 2024 Oct 3;111(10):2176-2189. doi: 10.1016/j.ajhg.2024.08.016. Epub 2024 Sep 11.

PMID: 39265574

Landscape of evolutionary arms races between transposable elements and KRAB-ZFP family. 

Kosuge M, Ito J, Hamada M.

Sci Rep. 2024 Oct 7;14(1):23358. doi: 10.1038/s41598-024-73752-7.

PMID: 39375372

Transposable Element (TE) insertion predictions from RNAseq inputs and TE impact on RNA splicing and gene expression in Drosophila brain transcriptomes. 

Azad MF, Tong T, Lau NC.

Mob DNA. 2024 Oct 9;15(1):20. doi: 10.1186/s13100-024-00330-z.

PMID: 39385293

Structure of TnsABCD transpososome reveals mechanisms of targeted DNA transposition. 

Wang S, Siddique R, Hall MC, Rice PA, Chang L.

Cell. 2024 Oct 8:S0092-8674(24)01071-7. doi: 10.1016/j.cell.2024.09.023. Online ahead of print.

PMID: 39383864

LINE1 modulate human T cell function by regulating protein synthesis during the life span. 

Burattin FV, Vadalà R, Panepuccia M, Ranzani V, Crosti M, Colombo FA, Ruberti C, Erba E, Prati D, Nittoli T, Montini G, Ronchi A, Pugni L, Mosca F, Ricciardi S, Abrignani S, Pietrasanta C, Marasca F, Bodega B.

Sci Adv. 2024 Oct 11;10(41):eado2134. doi: 10.1126/sciadv.ado2134. Epub 2024 Oct 9.

PMID: 39383231

MATES: a deep learning-based model for locus-specific quantification of transposable elements in single cell. 

Wang R, Zheng Y, Zhang Z, Song K, Wu E, Zhu X, Wu TP, Ding J.

Nat Commun. 2024 Oct 11;15(1):8798. doi: 10.1038/s41467-024-53114-7.

PMID: 39394211

Retrotransposon life cycle and its impacts on cellular responses. 

Luqman-Fatah A, Nishimori K, Amano S, Fumoto Y, Miyoshi T.

RNA Biol. 2024 Jan;21(1):11-27. doi: 10.1080/15476286.2024.2409607. Epub 2024 Oct 13.

PMID: 39396200 Review

Expression of most retrotransposons in human blood correlates with biological aging. 

Tsai YT, Seymen N, Thompson IR, Zou X, Mumtaz W, Gerlevik S, Mufti GJ, Karimi MM.

Elife. 2024 Oct 17;13:RP96575. doi: 10.7554/eLife.96575.

PMID: 39417397

Widespread HCD-tRNA derived SINEs in bivalves rely on multiple LINE partners and accumulate in genic regions. 

Martelossi J, Iannello M, Ghiselli F, Luchetti A.

Mob DNA. 2024 Oct 16;15(1):22. doi: 10.1186/s13100-024-00332-x.

PMID: 39415259

A unified framework to analyze transposable element insertion polymorphisms using graph genomes. 

Groza C, Chen X, Wheeler TJ, Bourque G, Goubert C.

Nat Commun. 2024 Oct 16;15(1):8915. doi: 10.1038/s41467-024-53294-2.

PMID: 39414821

LINE1 and PRC2 control nucleolar organization and repression of the 8C state in human ESCs. 

Zhang J, Ataei L, Mittal K, Wu L, Caldwell L, Huynh L, Sarajideen S, Tse K, Simon MM, Mazid MA, Cook DP, Trcka D, Kwan T, Hoffman MM, Wrana JL, Esteban MA, Ramalho-Santos M.

Dev Cell. 2024 Oct 14:S1534-5807(24)00574-4. doi: 10.1016/j.devcel.2024.09.024. Online ahead of print.

PMID: 39413784

Association of hyperactivated transposon expression with exacerbated immune activation in systemic lupus erythematosus. 

Wang FQ, Dang X, Su H, Lei Y, She CH, Zhang C, Chen X, Yang X, Yang J, Feng H, Yang W.

Mob DNA. 2024 Oct 19;15(1):23. doi: 10.1186/s13100-024-00335-8.

PMID: 39427224

Dynamic dysregulation of retrotransposons in neurodegenerative diseases at the single-cell level. 

Deng W, Citu C, Liu A, Zhao Z.

Genome Res. 2024 Oct 18. doi: 10.1101/gr.279363.124. Online ahead of print.

PMID: 39424325

Candida albicans isolates contain frequent heterozygous structural variants and transposable elements within genes and centromeres. 

Oggenfuss U, Todd RT, Soisangwan N, Kemp B, Guyer A, Beach A, Selmecki A.

Genome Res. 2024 Oct 22:gr.279301.124. doi: 10.1101/gr.279301.124. Online ahead of print.

PMID: 39438112

A ubiquitous mobile genetic element changes the antagonistic weaponry of a human gut symbiont. 

Sheahan ML, Flores K, Coyne MJ, García-Bayona L, Chatzidaki-Livanis M, Holst AQ, Smith RC, Sundararajan A, Barquera B, Comstock LE.

Science. 2024 Oct 25;386(6720):414-420. doi: 10.1126/science.adj9504. Epub 2024 Oct 24.

PMID: 39446952

Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis. 

Phan J, Chen B, Zhao Z, Allies G, Iannaccone A, Paul A, Cansiz F, Spina A, Leven AS, Gellhaus A, Schadendorf D, Kimmig R, Mettlen M, Tasdogan A, Morrison SJ.

Science. 2024 Oct 24:eado6836. doi: 10.1126/science.ado6836. Online ahead of print.

PMID: 39446896

YY1 is a transcriptional activator of the mouse LINE-1 Tf subfamily. 

Saha K, Nielsen GI, Nandani R, Zhang Y, Kong L, Ye P, An W.

Nucleic Acids Res. 2024 Oct 26:gkae949. doi: 10.1093/nar/gkae949. Online ahead of print.

PMID: 39460630

International congress on transposable elements (ICTE 2024) in Saint Malo: breaking down transposon waves and their impact. 

Lesage P, Brasset E, Cristofari G, Gilbert C, Mazel D, Rebollo R, Vitte C.

Mob DNA. 2024 Oct 26;15(1):25. doi: 10.1186/s13100-024-00334-9.

PMID: 39462418

Deep mining reveals the diversity of endogenous viral elements in vertebrate genomes. 

Nino Barreat JG, Katzourakis A.

Nat Microbiol. 2024 Nov;9(11):3013-3024. doi: 10.1038/s41564-024-01825-4. Epub 2024 Oct 22.

PMID: 39438719

Complete genomes of Asgard archaea reveal diverse integrated and mobile genetic elements. 

Valentin-Alvarado LE, Shi LD, Appler KE, Crits-Christoph A, De Anda V, Adler BA, Cui ML, Ly L, Leão P, Roberts RJ, Sachdeva R, Baker BJ, Savage DF, Banfield JF.

Genome Res. 2024 Oct 29;34(10):1595-1609. doi: 10.1101/gr.279480.124.

PMID: 39406503

Stem cell activity-coupled suppression of endogenous retrovirus governs adult tissue regeneration. 

Lyu Y, Kim SJ, Humphrey ES, Nayak R, Guan Y, Liang Q, Kim KH, Tan Y, Dou J, Sun H, Song X, Nagarajan P, Gerner-Mauro KN, Jin K, Liu V, Hassan RH, Johnson ML, Deliu LP, You Y, Sharma A, Pasolli HA, Lu Y, Zhang J, Mohanty V, Chen K, Yang YJ, Chen T, Ge Y.

Cell. 2024 Oct 23:S0092-8674(24)01155-3. doi: 10.1016/j.cell.2024.10.007. Online ahead of print.

PMID: 39476839

Regulatory transposable elements in the encyclopedia of DNA elements. 

Du AY, Chobirko JD, Zhuo X, Feschotte C, Wang T.

Nat Commun. 2024 Aug 31;15(1):7594. doi: 10.1038/s41467-024-51921-6.

PMID: 39217141

Retrotransposon addiction promotes centromere function via epigenetically activated small RNAs. 

Shimada A, Cahn J, Ernst E, Lynn J, Grimanelli D, Henderson I, Kakutani T, Martienssen RA.

Nat Plants. 2024 Sep 2. doi: 10.1038/s41477-024-01773-1. Online ahead of print.

PMID: 39223305

A centromere's obsession with transposons. 

Quadrana L.

Nat Plants. 2024 Sep 2. doi: 10.1038/s41477-024-01724-w. Online ahead of print.

PMID: 39223306

Human cytomegalovirus harnesses host L1 retrotransposon for efficient replication. 

Hwang SY, Kim H, Denisko D, Zhao B, Lee D, Jeong J, Kim J, Park K, Park J, Jeong D, Park S, Choi HJ, Kim S, Lee EA, Ahn K.

Nat Commun. 2024 Sep 2;15(1):7640. doi: 10.1038/s41467-024-51961-y.

PMID: 39223139

Natural transposable element insertions contribute to host fitness in model yeasts. 

Wang Y, Xu H, He Q, Wu Z, Han GZ.

Genome Biol Evol. 2024 Sep 4:evae193. doi: 10.1093/gbe/evae193. Online ahead of print.

PMID: 39228319

Recombinant origin and interspecies transmission of a HERV-K(HML-2)-related primate retrovirus with a novel RNA transport element. 

Williams ZH, Imedio AD, Gaucherand L, Lee DC, Mostafa SM, Phelan JP, Coffin JM, Johnson WE.

Elife. 2024 Jul 22;13:e80216. doi: 10.7554/eLife.80216.

PMID: 39037763

mSphere of Influence: When a sequencer is more than a sequencer. 

Billmyre RB.

mSphere. 2024 Sep 10:e0043324. doi: 10.1128/msphere.00433-24. Online ahead of print.

PMID: 39254324

Epigenetic therapy potentiates transposable element transcription to create tumor-enriched antigens in glioblastoma cells. 

Jang HJ, Shah NM, Maeng JH, Liang Y, Basri NL, Ge J, Qu X, Mahlokozera T, Tzeng SC, Williams RB, Moore MJ, Annamalai D, Chen JY, Lee HJ, DeSouza PA, Li D, Xing X, Kim AH, Wang T.

Nat Genet. 2024 Sep;56(9):1903-1913. doi: 10.1038/s41588-024-01880-x. Epub 2024 Sep 2.

PMID: 39223316

Hijackers, hitchhikers, or co-drivers? The mysteries of mobilizable genetic elements. 

Ares-Arroyo M, Coluzzi C, Moura de Sousa JA, Rocha EPC.

PLoS Biol. 2024 Aug 29;22(8):e3002796. doi: 10.1371/journal.pbio.3002796. eCollection 2024 Aug.

PMID: 39208359

The interplay between mobilome and resistome in Staphylococcus aureus. 

Contarin R, Drapeau A, François P, Madec J-Y, Haenni M, Dordet-Frisoni E.

mBio. 2024 Sep 17:e0242824. doi: 10.1128/mbio.02428-24. Online ahead of print.

PMID: 39287446

Two-factor authentication underpins the precision of the piRNA pathway. 

Dias Mirandela M, Zoch A, Leismann J, Webb S, Berrens RV, Valsakumar D, Kabayama Y, Auchynnikava T, Schito M, Chowdhury T, MacLeod D, Xiang X, Zou J, Rappsilber J, Allshire RC, Voigt P, Cook AG, Barau J, O'Carroll D.

Nature. 2024 Sep 18. doi: 10.1038/s41586-024-07963-3. Online ahead of print.

PMID: 39294378

Starships: a new frontier for fungal biology. 

Urquhart A, Vogan AA, Gluck-Thaler E.

Trends Genet. 2024 Sep 18:S0168-9525(24)00183-5. doi: 10.1016/j.tig.2024.08.006. Online ahead of print.

PMID: 39299886 Review.

Transposon-mediated genic rearrangements underlie variation in small RNA pathways. 

Zhang G, Félix MA, Andersen EC.

Sci Adv. 2024 Sep 20;10(38):eado9461. doi: 10.1126/sciadv.ado9461. Epub 2024 Sep 20.

PMID: 39303031

A comparative roadmap of PIWI-interacting RNAs across seven species reveals insights into de novo piRNA-precursor formation in mammals. 

Konstantinidou P, Loubalova Z, Ahrend F, Friman A, Almeida MV, Poulet A, Horvat F, Wang Y, Losert W, Lorenzi H, Svoboda P, Miska EA, van Wolfswinkel JC, Haase AD.

Cell Rep. 2024 Sep 19;43(10):114777. doi: 10.1016/j.celrep.2024.114777. Online ahead of print.

PMID: 39302833

TldR: TnpB's evolutionary shift from transposon nucleases to RNA-guided transcriptional regulators. 

Mohanraju P, Wu WY.

Trends Microbiol. 2024 Sep 19:S0966-842X(24)00230-0. doi: 10.1016/j.tim.2024.09.004. Online ahead of print.

PMID: 39304420

Retrotransposon-driven environmental regulation of FLC leads to adaptive response to herbicide. 

Raingeval M, Leduque B, Baduel P, Edera A, Roux F, Colot V, Quadrana L.

Nat Plants. 2024 Sep 27. doi: 10.1038/s41477-024-01807-8. Online ahead of print.

PMID: 39333353