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Fig. 5 | Mobile DNA

Fig. 5

From: Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes

Fig. 5

Escape of ORF1p granules from SLE neutrophils during NETosis. A., ORF1p (red) in 6 or 7 SLE neutrophils undergoing NETosis. A normal neutrophil also appears in the bottom left panel. The approximate location of the neutrophil before NETosis is indicated with a dotted circle. Externalized, free or DNA-associated ORF1p granules are indicated with white arrows. B., ORF1p (red) remains intracellular in neutrophils undergoing apoptosis as indicated by activated caspase-3 (green). C., ORF1p (red) in a neutrophil undergoing pyroptosis as indicated by cell ballooning and the absence of activated caspase-3 (green). At least one ORF1p granule appears to have escaped (white arrow). The shown images were taken with 100 X magnification

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ISSN: 1759-8753