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Fig. 4 | Mobile DNA

Fig. 4

From: Subcellular location of L1 retrotransposon-encoded ORF1p, reverse transcription products, and DNA sensors in lupus granulocytes

Fig. 4

The DNA sensors cGAS and ZBP1 in SLE neutrophils. A., Expression of cGAS and ZBP1 in healthy (n = 12) and SLE (n = 15) neutrophils by RNA sequencing. B., Staining of two SLE neutrophils for ORF1p (red) and cGAS (green). C., Enlarged view of the bottom neutrophil in B to better visualize the lack of overlap between ORF1p and cGAS. D., Staining of two SLE neutrophils for ORF1p (red) and ZBP1 (green). E., Enlarged view of the last image in D to better visualize the overlap between ORF1p and ZBP1. F., ZBP1 and cGAS in SLE neutrophils. G., MOV10 and ZBP1. Last panels are staining with secondary antibody alone. H., Enlarged view of the last image in F to better visualize the partial co-localization of ORF1p and ZBP1. I., Eight representative healthy control neutrophils stained for ZBP1. J., Enlarged view of the top row neutrophil in G to visualize the co-localization of MOV10 and ZBP1. K., Eight healthy control neutrophils stained for cGAS. All images are with 100 X magnification

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ISSN: 1759-8753