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Fig. 3 | Mobile DNA

Fig. 3

From: Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

Fig. 3

The sequence conservation analyses of the zinc finger domains of KRAB-ZFPs. (A) A schematic model of the interaction between a typical C2H2 zinc finger domain of KRAB-ZFP and its target DNA. (B) Sequence conservation analyses of the amino acid sequences (top) and the corresponding nucleic acid sequences (bottom) according to the regions shown in the bean green box or the pale purple box in (A). The related sequences were extracted from all the KRAB-Zfps across the mouse genome (a), within the KRAB-Zfps in cluster 3 (b), within the clusters 4 and 5 (c), or from one randomly selected KRAB-Zfp gene, namely KRAB-Zfp987 (d)

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Mobile DNA

ISSN: 1759-8753